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Updated: Oct 11, 2026
Inducing Daytime Circadian Phase Shifts Using Chemogenetic and Spectral Approaches
Published on: June 12, 2026
A melatonin agonist facilitates circadian resynchronization in old hamsters after abrupt shifts in the light-dark
L Weibel1, F W Turek, E Mocaer
1Centre d'Etudes des Rythmes Biologiques, School of Medicine, H opital Erasme, Université Libre de Bruxelles, Route de Lennik, 808, 1070, Brussels, Belgium.
Abstract:
Age-related changes in the mammalian circadian system may be associated with a decline in circulating melatonin levels. Using 'jet lag' paradigms involving abrupt shifts in the light-dark cycle, we showed that a melatonin agonist, S-20098, accelerated by approximately 25% resynchronization of the circadian activity rhythm in old hamsters to the new light-dark cycle. It suggests the usefulness of melatonin-related compounds to treat circadian disorders associated with aging.
