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08:56
Fate Mapping of Human Embryonic Stem Cells by Teratoma Formation
Published on: August 1, 2010
Cotesia kariyai teratocytes: growth and development
1Applied Entomology, Graduate School of Bio-Agricultural Sciences, Nagoya University, Chikusa, 464-8601, Nagoya, Japan
Journal of Insect Physiology
|October 18, 2000
Summary
Teratocytes, released by Cotesia kariyai wasp embryos, grow and secrete proteins, regulating the host Pseudaletia separata. These parasitic cells show increased size, DNA content, and ploidy during development.
Area of Science:
- Insect biology
- Parasitology
- Cell biology
Background:
- Teratocytes are embryonic cells released by parasitic wasps.
- Understanding teratocyte development is crucial for insect host-parasite interactions.
Purpose of the Study:
- To investigate the growth, development, and function of teratocytes in the Cotesia kariyai-Pseudaletia separata system.
- To determine the role of teratocytes in regulating host physiology.
Main Methods:
- Microscopy (SEM) for surface morphology.
- DNA content and ploidy analysis.
- In vitro protein synthesis and secretion analysis using (35)S-methionine labeling.
Main Results:
- C. kariyai embryos release ~163 teratocytes.
- Teratocyte diameter increases to 77 µm by day 7, with significant population variation later.
- DNA content doubles and ploidy increases 4-fold by day 7.
- Teratocytes exhibit microvilli and bleb structures, and synthesize/secrete proteins until day 9-10.
Conclusions:
- Teratocytes are active throughout later developmental stages.
- Teratocytes play a role in regulating the host's physiological state.
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