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Updated: Sep 14, 2026
Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous
1Department of Experimental Clinical Oncology, Danish Cancer Society, Nörrebrogade 44, DK-8000, Aarhus C, Denmark.
Introduction:
In a previous report of 35 patients we suggested that pretreatment tumour pO(2) measured by Eppendorf electrodes was predictive of loco-regional control after primary radiotherapy in advanced head and neck squamous cell carcinomas. Radiother Oncol 41 (1996) 31.
Materials And Methods:
The aim of the present study was to test this hypothesis. Therefore, pretreatment tumour pO(2) was measured using the same assay in a new cohort of 35 patients that received an identical treatment being primary radiation along with a total dose of 66-68 Gy as 2 Gy per fraction over 5.5 or 6.5 weeks. Treatment outcome was evaluated as loco-regional control probability at 2 years using the same oxygenation parameter and applying the cut-off value from the first study.
Results:
In agreement with the hypothesis generating study we found that the loco-regional tumour control probability was significantly higher (90%) among well oxygenated tumours as compared with the hypoxic subgroup (45%) (P=0. 04).
Conclusion:
This study confirmed that pretreatment tumour oxygenation status was prognostic of loco-regional tumour control after primary radiation alone in advanced head and neck squamous cell carcinoma.
