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Related Experiment Videos

Acute changes in cochlear potentials due to cisplatin.

N Tsukasaki1, C A Whitworth, L P Rybak

  • 1Department of Surgery, Southern Illinois University School of Medicine,Springfield, IL 62794-9638, USA.

Hearing Research
|October 18, 2000
PubMed
Summary
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Cisplatin ototoxicity rapidly reduces cochlear function, indicated by decreased endocochlear potential (EP) and cochlear microphonics (CM). Early changes stem from stria vascularis alterations, preceding significant hair cell damage.

Area of Science:

  • Ototoxicity research
  • Auditory neuroscience
  • Inner ear physiology

Background:

  • Cisplatin is a common chemotherapy agent with known ototoxic side effects.
  • The precise early mechanisms of cisplatin-induced hearing loss are not fully understood.
  • Hair cells and stria vascularis are critical for auditory function and are potential targets of ototoxicity.

Purpose of the Study:

  • To investigate the early effects of cisplatin on hair cells and the stria vascularis.
  • To simultaneously observe the impact of cisplatin on endocochlear potential (EP) and cochlear microphonics (CM).
  • To correlate electrophysiological changes with morphological alterations in the cochlea.

Main Methods:

  • Adult chinchillas were treated with topical cisplatin or saline on the round window.

Related Experiment Videos

  • Endocochlear potential (EP) and cochlear microphonics (CM) were recorded for 12-14 hours.
  • Scanning electron microscopy was used to assess morphological changes in cochlear structures.

    • Main Results:

    • A profound reduction in both EP and CM amplitudes was observed within 12-14 hours.
    • A strong correlation existed between EP and CM amplitude reductions.
    • Minimal outer hair cell degeneration was noted at 12-14 hours, despite significant functional decline.

    Conclusions:

    • Early cisplatin ototoxicity primarily affects cochlear function through stria vascularis alterations, leading to EP reduction.
    • Subsequent hair cell damage contributes to later-stage cochlear dysfunction.
    • These findings highlight the stria vascularis as an early target in cisplatin-induced ototoxicity.