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Related Experiment Videos

Drug targeting.

V P Torchilin1

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, MA 02115, USA. vtorchil@lynx.neu.edu

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|October 18, 2000
PubMed
Summary

Drug targeting enhances pharmaceutical delivery by concentrating medications at specific sites, minimizing side effects. Various methods, including passive and active targeting with carriers like liposomes, improve drug efficacy and reduce toxicity.

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Area of Science:

  • Pharmacology
  • Biotechnology
  • Materials Science

Background:

  • Systemic drug administration faces challenges like poor biodistribution, lack of target specificity, and dose-dependent toxicity.
  • Achieving high local drug concentrations often requires large total doses, leading to adverse side effects.

Purpose of the Study:

  • To explore drug targeting strategies for improving pharmaceutical delivery and overcoming limitations of systemic administration.
  • To review various drug targeting methods and pharmaceutical carriers for enhanced therapeutic and diagnostic agent delivery.

Main Methods:

  • Overview of drug targeting principles including direct application, passive targeting (e.g., Enhanced Permeability and Retention effect), physical targeting, magnetic targeting, and ligand-based targeting.
  • Discussion of pharmaceutical carriers such as polymers, microcapsules, liposomes, and micelles used for in vivo targeted drug delivery.

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  • Comparison of direct drug conjugation versus microreservoir systems, highlighting advantages of the latter for drug loading and controlled release.

    • Main Results:

    • Drug targeting aims for predominant drug accumulation in pathological sites, resolving issues of uneven distribution and toxicity.
    • Ligand-based targeting offers broad opportunities, with various carriers successfully employed for in vivo delivery.
    • Microreservoir systems demonstrate advantages in loading capacity, size/permeability control, and efficient vector molecule utilization.

    Conclusions:

    • Drug targeting strategies significantly improve drug delivery efficiency and safety compared to traditional systemic administration.
    • The selection of appropriate targeting methods and carriers is crucial for successful therapeutic and diagnostic applications.
    • Advanced drug delivery systems, particularly microreservoir-type carriers, hold great promise for targeted pharmaceutical interventions.