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Extracorporeal model for study of factors affecting thrombus formation
Thrombosis Et Diathesis Haemorrhagica
|September 30, 1975
Summary
This study used a canine extracorporeal shunt model to investigate thrombus formation on foreign surfaces. Heparin proved most effective in preventing clot formation, highlighting its potential as an antithrombotic agent.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Materials Science
Background:
- Thrombus formation on foreign surfaces is a critical issue in medical devices.
- Understanding factors influencing thrombosis is essential for improving biomaterial safety and efficacy.
Purpose of the Study:
- To investigate factors influencing thrombus formation in an extracorporeal shunt model.
- To evaluate the antithrombotic efficacy of heparin, acetylsalicylic acid, and lysozyme.
Main Methods:
- Utilized a canine extracorporeal shunt model with silicone rubber tubing.
- Employed plastic flow chambers with defined geometry and controlled blood flow rates (100-400 ml/min).
- Administered various antithrombotic agents (heparin, aspirin, lysozyme) alone and in combination.
Main Results:
- Thrombus weight increased with exposure time up to 20 minutes and decreased with higher flow rates.
- Heparin significantly reduced thrombus accumulation by approximately 50%.
- Aspirin and lysozyme showed no significant antithrombotic effect under experimental conditions; heparin's efficacy was not affected by their presence.
Conclusions:
- The developed canine model provides a valuable platform for studying thrombus formation influenced by blood flow and biomaterials.
- Heparin demonstrates potent antithrombotic activity in this model, suggesting its clinical relevance.
- Further research can explore biomaterial interactions and optimize antithrombotic strategies.