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Pre- and postsynaptic effects of eugenol and related compounds on Helix pomatia L. neurons
1Department of Comparative Physiology, József Attila University, Szeged, Hungary. 4532.387@stud.u.-szeged.hu
Acta Biologica Hungarica
|October 18, 2000
Abstract:
We showed how eugenol blocks the synaptic transmission and gave a possible interpretation how it inhibits the excitation-contraction coupling that several authors described previously. Eugenol acts both in the pre- and postsynaptic side of the neurons. It blocks the Ca2+-currents, decreases the membrane potential of the neurons, increases the inward resistance and decreases the GABA, ACh and glutamate evoked excitatory responses in submillimolar concentration.