Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physiological and pharmacological studies on nematodes.

R J Walker1, C J Franks, D Pemberton

  • 1Department of Physiology and Pharmacology, School of Biological Sciences, University of Southampton, UK.

Acta Biologica Hungarica
|October 18, 2000
PubMed
Summary

Nematodes utilize classical transmitters like acetylcholine (ACh) and gamma-aminobutyric acid (GABA), alongside neuroactive peptides, to regulate muscle function. These molecules play crucial roles in the nervous system, impacting muscle contractions and modulating neurotransmission.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Equality, Diversity and Inclusivity dynamics and commitment profiles of comparator clinical Radiography and related medical radiation science journals.

Radiography (London, England : 1995)·2025
Same author

Establishing a Pan-European, multi-disciplinary taphonomic research Infrastructure: The 'UK-Netherlands decomposition experimental research (UNDER) Group'.

Science & justice : journal of the Forensic Science Society·2025
Same author

Comparing Hearing Loss in Children with Adults Living with Sickle Cell Disease and Sickle Cell Traits.

Nigerian journal of clinical practice·2024
Same author

Background levels of body fluids and DNA on the shaft of the penis and associated underpants in the absence of sexual activity.

Science & justice : journal of the Forensic Science Society·2023
Same author

Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses.

Research square·2023
Same author

Scoping Review of Predisposing Factors Associated with Sensorineural Hearing Loss in Sickle Cell Disease.

West African journal of medicine·2023

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Parasitology

Background:

  • Nematodes possess complex nervous systems employing both classical neurotransmitters and neuroactive peptides.
  • Acetylcholine (ACh) and gamma-aminobutyric acid (GABA) are key neurotransmitters in nematode somatic muscle.
  • 5-hydroxytryptamine (5-HT) acts as an excitatory transmitter in pharyngeal muscles and modulates somatic muscle activity.

Purpose of the Study:

  • To investigate the diverse roles of classical transmitters and neuroactive peptides in nematode nervous systems.
  • To elucidate the mechanisms underlying neurotransmitter and peptide actions on nematode muscles.
  • To understand how these signaling molecules modulate neuromuscular functions in nematodes like Ascaris suum and Caenorhabditis elegans.

Main Methods:

Related Experiment Videos

  • Electrophysiological recordings to assess muscle responses to various neurotransmitters and peptides.
  • Biochemical assays to investigate second messenger system involvement (e.g., adenylate cyclase, inositol phosphate).
  • Pharmacological characterization of neurotransmitter and peptide actions on somatic and pharyngeal muscles.

    • Main Results:

    • Acetylcholine (ACh) and gamma-aminobutyric acid (GABA) mediate excitatory and inhibitory signals in somatic body wall muscle, respectively.
    • 5-hydroxytryptamine (5-HT) excites pharyngeal muscle and inhibits ACh-induced somatic muscle contractions via distinct signaling pathways.
    • RFamide peptides exhibit diverse modulatory effects, including excitation and inhibition of somatic muscle, and biphasic actions on pharyngeal muscle, acting pre- or postsynaptically.

    Conclusions:

    • Nematodes utilize a sophisticated array of classical transmitters and neuroactive peptides for precise neuromuscular control.
    • Peptide actions are mediated through second messenger systems and significantly modulate the effects of classical transmitters like ACh.
    • Understanding these neurochemical mechanisms provides insights into nematode behavior and potential targets for intervention.