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Related Experiment Videos

Antibiotics for sore throat.

Del Mar CB1, P P Glasziou, A B Spinks

  • 1Centre for General Practice, University of Queensland Medical School, Brisbane Queensland 4006, AUSTRALIA. c.delmar@mailbox.uq.edu.au

The Cochrane Database of Systematic Reviews
|October 18, 2000
PubMed
Summary
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Antibiotics offer some benefits for sore throat, reducing symptoms and complications like rheumatic fever and otitis media. However, the overall benefits are modest, with only a slight reduction in symptom duration.

Area of Science:

  • Infectious Diseases
  • General Practice
  • Evidence-Based Medicine

Background:

  • Sore throat is a common ailment managed in primary care.
  • Antibiotics are frequently prescribed for sore throats and other upper respiratory infections, despite the condition often resolving spontaneously.

Purpose of the Study:

  • To evaluate the efficacy of antibiotic treatment for sore throat.
  • To assess the impact of antibiotics on symptom duration and the incidence of complications.

Main Methods:

  • A systematic literature review was conducted, searching databases from 1945 to 1999.
  • Included studies were trials comparing antibiotic treatment against a placebo for sore throat.
  • Outcomes assessed included typical symptoms (soreness, headache, fever) and complications (suppurative and non-suppurative).

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Main Results:

  • Antibiotics significantly reduced suppurative complications such as acute otitis media and quinsy.
  • A reduction in non-suppurative complications like acute rheumatic fever was observed.
  • Symptom duration was shortened by approximately one day, with greatest effect around day 3.5.
  • Antibiotic effectiveness was greater when a throat swab for Streptococcus was positive.

Conclusions:

  • Antibiotics provide relative benefits in managing sore throat symptoms and preventing complications.
  • The absolute benefits of antibiotic treatment for sore throat are modest.
  • Widespread antibiotic use for sore throat results in many individuals receiving treatment without deriving significant benefit.