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Related Experiment Videos

Antidepressants for smoking cessation.

J R Hughes1, L F Stead, T Lancaster

  • 1Department of Psychiatry, University of Vermont, 38 Fletcher Place, Burlington, Vermont 05401-1419, USA. john.hughes@uvm.edu

The Cochrane Database of Systematic Reviews
|October 18, 2000
PubMed
Summary
This summary is machine-generated.

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Certain antidepressants, such as bupropion and nortriptyline, can help individuals quit smoking long-term. These medications may aid smoking cessation by impacting neurotransmitters involved in nicotine addiction.

Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Clinical Trials

Background:

  • Depression can be a symptom of nicotine withdrawal, and smoking cessation may precipitate depression.
  • Smoking may be linked to neurotransmitter deficits (dopamine, serotonin, norepinephrine) that antidepressants can influence.

Purpose of the Study:

  • To evaluate the effectiveness of antidepressant medications for achieving long-term smoking cessation.
  • To review specific drugs including bupropion, doxepin, fluoxetine, imipramine, moclobemide, nortriptyline, selegiline, sertraline, tryptophan, and venlafaxine.

Main Methods:

  • Systematic review of randomized controlled trials comparing antidepressant drugs to placebo or alternative therapies.
  • Included trials with a minimum of six months follow-up, extracting data on study population, drug therapy, outcomes, and randomization.

Related Experiment Videos

  • Utilized a fixed-effects model for meta-analysis where appropriate, focusing on biochemically validated abstinence rates.

    • Main Results:

    • Bupropion and nortriptyline demonstrated an increase in smoking cessation rates.
    • One trial indicated that combining bupropion with a nicotine patch yielded higher quit rates than the patch alone.

    Conclusions:

    • Specific antidepressants, namely bupropion and nortriptyline, show efficacy in aiding smoking cessation.
    • Further research is needed to determine if the observed benefits are drug-specific or a general class effect of antidepressants.