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Related Experiment Videos

Glycerol for acute stroke.

E Righetti1, M G Celani, T Cantisani

  • 1Stroke Service, USL 2, Via Guerra 17, Perugia, ITALY, 06127. istitaly@unipg.it

The Cochrane Database of Systematic Reviews
|October 18, 2000
PubMed
Summary
This summary is machine-generated.

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Intravenous glycerol may reduce short-term death in ischemic stroke patients, but evidence is limited. Long-term benefits and safety require further investigation, cautioning against routine use.

Area of Science:

  • Neurology
  • Clinical Trials
  • Stroke Research

Background:

  • Brain edema is a critical factor in early mortality following stroke.
  • Intravenous glycerol, a hyperosmolar agent, is proposed to mitigate brain edema.

Purpose of the Study:

  • To evaluate the efficacy and safety of intravenous glycerol in acute ischemic and hemorrhagic stroke.
  • To assess glycerol's impact on short-term and long-term mortality and functional outcomes.

Main Methods:

  • Systematic review of completed randomized and quasi-randomized controlled trials.
  • Inclusion of published and unpublished studies evaluating clinical outcomes with early intravenous glycerol administration.
  • Data extraction and quality assessment by independent reviewers, analyzing mortality and adverse effects.

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Main Results:

  • Eleven trials involving 945 patients were analyzed.
  • A non-significant reduction in short-term mortality was observed overall (OR 0.78).
  • Significant short-term mortality reduction in definite/probable ischemic stroke (OR 0.65), but no long-term benefit (OR 0.98).
  • Limited data on functional outcomes showed a non-significant trend towards better outcomes (OR 0.73).
  • Hemolysis identified as a potential adverse effect.

Conclusions:

  • Intravenous glycerol may offer a modest short-term survival benefit in ischemic stroke, though the effect size is small.
  • Results should be interpreted cautiously due to small patient numbers and pre-CT era trial designs.
  • Lack of demonstrated long-term benefit does not support routine or selective use of glycerol in acute stroke management.