Related Experiment Video
Updated: Aug 14, 2026
Real-time Imaging of Leukotriene B4 Mediated Cell Migration and BLT1 Interactions with β-arrestin
Published on: December 23, 2010
Leukotriene receptor antagonists for non-cystic fibrosis bronchiectasis
1Aintree Chest Centre, University Hospital, Aintree, Aintree Chest Centre, University Hospital Aintree, Lower Lane, Liverpool, Merseyside, UK, L9 7AL. j.corless@bigfoot.com
Background:
Leukotriene receptor antagonists are a new class of drug that were initially identified for use in asthma. As they have an effect on neutrophil mediated inflammation, they may be of benefit in bronchiectasis.
Objectives:
To determine whether leukotriene receptor antagonists have any additive benefit over and above conventional treatment for bronchiectasis (usually consisting of antibiotics and postural drainage).
Search Strategy:
The Cochrane Airways Group clinical trials register derived from MEDLINE, EMBASE and hand searching of major journals was searched using the terms:Bronchiec* AND leukotrien* OR anti-leuk* OR cysteinyl, Bronchiec* AND monteluk*, Bronchiec* AND zafirluk*
Selection Criteria:
Only randomised, controlled trials were considered
Data Collection And Analysis:
The results of searches were analysed by both authors
Main Results:
No randomised, controlled trials were identified
Reviewer'S Conclusions:
Further research is required to establish any benefit from the use of leukotriene antagonists in bronchiectasis.
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