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Related Experiment Videos

Single dose dihydrocodeine for acute postoperative pain.

J E Edwards1, H J McQuay, R A Moore

  • 1Pain Research Unit, Nuffield Department of Anaesthetics, Churchill Hospital, Old Road, Oxford, UK, OX3 7LJ. jayne.edwards@pru.ox.ac.uk

The Cochrane Database of Systematic Reviews
|October 18, 2000
PubMed
Summary
This summary is machine-generated.

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A single 30 mg dose of dihydrocodeine is insufficient for moderate to severe postoperative pain. Ibuprofen 400 mg demonstrated superior analgesic efficacy and safety compared to dihydrocodeine.

Area of Science:

  • Pharmacology
  • Pain Management
  • Clinical Trials

Background:

  • Dihydrocodeine, a synthetic opioid analgesic, is used for postoperative pain and as an antitussive.
  • Assessing the relative efficacy and harm of different analgesics is crucial for treatment selection.
  • Quantitative analysis of analgesic treatments requires comparison with control under similar clinical conditions.

Purpose of the Study:

  • To quantitatively assess the analgesic efficacy of single-dose dihydrocodeine versus placebo.
  • To evaluate the adverse effects associated with single-dose dihydrocodeine in randomized trials.
  • To compare dihydrocodeine's efficacy and safety against placebo in moderate to severe postoperative pain.

Main Methods:

  • Systematic literature search of multiple electronic databases and reference lists.

Related Experiment Videos

  • Inclusion criteria: randomized, double-blind, placebo-controlled trials of adult patients with moderate to severe postoperative pain.
  • Data extraction focused on pain relief (at least 50% reduction) and adverse effects over 4-6 hours.

    • Main Results:

    • Four randomized trials met inclusion criteria, all assessing oral dihydrocodeine.
    • Dihydrocodeine 30 mg showed a Number-Needed-to-Treat (NNT) of 8.1 for 50% pain relief compared to placebo.
    • Significantly more adverse effects were reported with dihydrocodeine 30 mg than placebo; ibuprofen 400 mg was superior to dihydrocodeine.

    Conclusions:

    • A single 30 mg dose of dihydrocodeine is inadequate for managing moderate to severe postoperative pain.
    • Ibuprofen 400 mg demonstrated statistically superior efficacy over dihydrocodeine (30 mg or 60 mg).
    • Further research may be needed to establish optimal dihydrocodeine dosing or alternative analgesics.