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Testosterone replacement: when is there a role?

A Morales1

  • 1Queens University, Department of Urology, Kingston General Hospital, Kingston, Canada. Moralesa@post.queensu.ca

International Journal of Impotence Research
|October 18, 2000
PubMed
Summary
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Diagnosing male hypogonadism requires biochemical testing, primarily serum testosterone levels. Androgen supplementation may treat erectile dysfunction in diagnosed hypogonadal men, with careful monitoring essential.

Area of Science:

  • Endocrinology
  • Urology

Background:

  • Hypogonadism is an infrequent cause of erectile dysfunction (ED).
  • Clinical diagnosis of hypogonadal states in adult males is challenging.
  • Biochemical confirmation is necessary for accurate diagnosis.

Purpose of the Study:

  • To outline diagnostic methods for hypogonadism in men with ED.
  • To provide recommendations for androgen supplementation in hypogonadal men with ED.
  • To emphasize the importance of monitoring and managing co-morbidities.

Main Methods:

  • Determination of serum total testosterone levels.
  • Assessment of sex hormone-binding globulin (SHBG) or bioavailable testosterone.
  • Trial of androgen supplementation in diagnosed cases without contraindications.

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Main Results:

  • Total testosterone and SHBG assessment are reliable diagnostic tools.
  • Androgen supplementation is a viable treatment for hypogonadal ED.
  • Monitoring and addressing co-morbidities are crucial for treatment success.

Conclusions:

  • Hypogonadism diagnosis requires biochemical assessment, not just clinical evaluation.
  • Androgen therapy is indicated for hypogonadal ED when appropriate.
  • A structured approach to diagnosis, treatment, and monitoring is recommended.