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The nonfunctional allele TCRBV6S1B is strongly associated with Helicobacter pylori infection
E Kunstmann1, C Hardt, E Elitok
1Department of Molecular Human Genetics, Ruhr-University, 44780 Bochum, Germany. Erdmute.M.Kunstmann@rurh-uni-bochum.de
Infection and Immunity
|October 18, 2000
Abstract:
To determine genetic susceptibility factors for Helicobacter pylori infection, polymorphic T-cell receptor gene elements were investigated in 203 H. pylori-infected individuals and 180 uninfected individuals (controls). H. pylori infection is highly associated with individuals homozygous for the nonfunctional TCRBV6S1B element (odds ratio = 5.9; chi(2) = 13; P = 0.00032; P value corrected for multiple comparisons [Bonferroni correction] = 0. 00063).