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Related Experiment Videos

Lower peak bone mass and its decline.

M F Sowers1

  • 1School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.

Bailliere'S Best Practice & Research. Clinical Endocrinology & Metabolism
|October 19, 2000
PubMed
Summary

Pre-menopausal bone density predicts two-thirds of osteoporotic fracture risk. Interventions during pre- and peri-menopause can modify osteoporosis frequency in older women.

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Premature menopause in a multi-ethnic population study of the menopause transition.

Human reproduction (Oxford, England)·2003

Area of Science:

  • Reproductive endocrinology
  • Bone metabolism
  • Geriatric medicine

Background:

  • Osteoporotic fractures pose a significant health risk, particularly in older women.
  • Pre-menopausal bone mineral density is a key predictor of future fracture risk.
  • Osteoporosis development is influenced by hormonal changes and lifestyle factors.

Purpose of the Study:

  • To highlight the predictive value of pre-menopausal bone mineral density for osteoporotic fractures.
  • To explore modifiable risk factors for osteoporosis in pre- and peri-menopausal women.
  • To identify key periods and factors influencing bone health and osteoporosis risk.

Main Methods:

  • Review of evidence linking pre-menopausal bone mineral density to fracture risk.
  • Analysis of factors affecting peak bone mineral density and bone loss.
  • Identification of hormonal and lifestyle risk factors for osteoporosis.

Main Results:

  • Two-thirds of osteoporotic fracture risk can be predicted by pre-menopausal bone mineral density.
  • Altered reproductive hormone concentrations (e.g., during adolescence, pre-menopause, peri-menopause) impact bone density.
  • Calciotrophic hormone alterations (e.g., corticosteroid therapy) and lifestyle factors (alcohol, smoking, inactivity, diet) contribute to bone loss.

Conclusions:

  • Implementing intervention strategies during pre- and peri-menopausal periods can potentially reduce osteoporosis frequency in older women.
  • Monitoring women with altered hormone concentrations or specific lifestyle practices is crucial for early identification of osteoporosis risk.
  • Effective intervention involves treating underlying conditions and vigilant monitoring of high-risk individuals.

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