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Updated sequence information and proposed nomenclature for bla(TEM) genes and their promoters
V Leflon-Guibout1, B Heym, M Nicolas-Chanoine
1Microbiology Department, Hôpital Ambroise-Paré, Université Paris V, 92100 Boulogne-Billancourt, France.
Antimicrobial Agents and Chemotherapy
|October 19, 2000
Abstract:
The nucleotide sequences of 59 bla(TEM) genes encoding inhibitor-resistant TEM enzymes showed great genetic variability and were associated with different types of promoters. These findings led us to suggest an updated bla(TEM) gene nomenclature based on the origin of the bla(TEM) gene (bla(TEM-1A), bla(TEM-1B), bla(TEM-1C), bla(TEM-1D), bla(TEM-1E), and bla(TEM-1F)) and the promoter type.