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Biochemical engineering aspects of solid state bioprocessing.

D A Mitchell1, M Berovic, N Krieger

  • 1Departamento de Solos, Universidade Federal do Paraná, Brazil.

Advances in Biochemical Engineering/Biotechnology
|October 19, 2000
PubMed
Summary
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Solid-state fermentation (SSF) has potential but few commercial uses due to complex heat/mass transfer limits. Recent advances improve understanding, but large-scale validation of models is needed for wider application.

Area of Science:

  • Biochemical Engineering
  • Biotechnology
  • Industrial Microbiology

Background:

  • Solid-state fermentation (SSF) technology has historical use and recent resurgence.
  • Despite its potential, large-scale commercial applications remain limited.
  • Complexity arises from intrinsic macroscale and microscale heat and mass transfer limitations.

Purpose of the Study:

  • To review the current understanding of biochemical engineering aspects in SSF processing.
  • To cover fermentation, substrate/inoculum preparation, downstream processing, and waste disposal.
  • To highlight advances in controlling SSF bioreactor performance.

Main Methods:

  • Review of current literature on SSF biochemical engineering.
  • Analysis of intraparticle processes (enzyme/oxygen diffusion).

Related Experiment Videos

  • Examination of macroscale heat transfer processes (conduction, convection, evaporation).
  • Assessment of mathematical modeling's role in SSF design and operation.

    • Main Results:

    • Significant progress in understanding SSF bioreactor performance control over the last decade.
    • Mathematical models have guided SSF bioreactor design and operation.
    • Models are primarily based on laboratory-scale data.

    Conclusions:

    • Understanding of SSF heat and mass transfer limitations has improved.
    • Mathematical modeling is crucial for SSF process optimization.
    • Urgent need to validate laboratory-scale models with large-scale bioreactor data for commercial viability.