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Updated: Jul 18, 2026
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Implantation of the Syncardia Total Artificial Heart
Published on: July 18, 2014
First permanent implant of the Jarvik 2000 Heart
S Westaby1, A P Banning, R Jarvik
1Oxford Heart Centre, John Radcliffe Hospital, UK. swestaby@AHF.org.uk
Lancet (London, England)
|October 19, 2000
Summary
The Jarvik 2000 Heart, a novel left-ventricular assist device, shows promise for end-stage heart failure patients. This innovative device improved patient function and resolved symptoms with no short-term complications.
Area of Science:
- Cardiology
- Biomedical Engineering
- Medical Devices
Background:
- Heart failure presents a significant public health challenge with limited donor hearts available.
- Current medical therapies offer poor quality and duration of life for end-stage heart failure patients.
- There is a critical need for alternative long-term solutions for end-stage heart failure.
Purpose of the Study:
- To evaluate the efficacy and safety of the Jarvik 2000 Heart as a long-term solution for end-stage heart failure.
- To assess the impact of the intraventricular device on native heart function and heart failure symptoms.
- To investigate the systemic effects of the left-ventricular assist device.
Main Methods:
- A prospective clinical trial was conducted involving the implantation of the Jarvik 2000 Heart.
- The study included a 61-year-old male patient with New York Heart Association functional class IV dilated cardiomyopathy.
- The left-ventricular assist device featured an innovative power delivery system and intraventricular placement.
Main Results:
- The Jarvik 2000 Heart successfully sustained the patient's circulation, demonstrating practicality and user-friendliness.
- Significant improvements were observed in exercise tolerance, myocardial function, and end-organ function within 6 weeks.
- Heart failure symptoms resolved, with no adverse effects from continuous decreased pulse-pressure perfusion, minimal hemolysis, and no device-related complications.
Conclusions:
- The initial success suggests a potential new treatment modality for end-stage heart failure.
- Long-term mechanical reliability will be crucial in determining the device's ultimate role.
- The skull-mounted power source healed well and was unobtrusive.
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