Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cost of linkage versus association methods.

C I Amos¹, G Page

¹Department of Epidemiology and Biomathematics, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.

Advances in Genetics

|October 19, 2000

Summary

Identifying genetic factors for complex diseases requires evaluating linkage and association methods. The best approach depends on population disequilibrium, which needs further assessment for effective study planning.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Breast cancer screening in women taking hormone replacement therapy needs updating.

Facts, views & vision in ObGyn·2024

Same author

Sex and gender differences in healthcare utilisation trajectories: a cohort study among Quebec workers living with chronic pain.

BMJ open·2023

Same author

Review: Targeted nutrition in gestating sows: opportunities to enhance sow performance and piglet vitality.

Animal : an international journal of animal bioscience·2023

Same author

Effect of low colostrum intake on gastrointestinal development and uterine and cervical morphometrical architecture in the neonatal gilt.

Animal : an international journal of animal bioscience·2023

Same author

Strategies aimed at preventing long-term opioid use in trauma and orthopaedic surgery: a scoping review.

BMC musculoskeletal disorders·2022

Same author

Exploiting digital droplet PCR and Next Generation Sequencing technologies to determine the relative abundance of individual Eimeria species in a DNA sample.

Veterinary parasitology·2021

Area of Science:

Genetic epidemiology
Statistical genetics

Background:

Genetic linkage methods are effective for simple diseases.
Complex diseases involve multiple genetic factors with minor individual roles.
Evaluating linkage versus association methods is crucial for complex disease genetics.

Purpose of the Study:

Compare the cost-effectiveness of genetic linkage and association methods.
Identify genetic factors influencing a quantitative trait locus (QTL) explaining 10% of variability.
Assess the impact of population disequilibrium on method choice.

Main Methods:

Comparative analysis of genetic linkage and association study designs.
Evaluation of cost-effectiveness based on population parameters.
Focus on identifying genetic factors for a QTL with 10% interindividual variability.

Main Results:

The optimal analytical scheme (linkage vs. association) is contingent on the degree of population disequilibrium.
Association studies require linkage disequilibrium, which is often not well-characterized.
Cost-effectiveness varies based on the chosen analytical method and population characteristics.

Conclusions:

The choice between linkage and association methods for genetic factor identification depends on population disequilibrium levels.
Inadequate assessment of population disequilibrium complicates the planning of association studies.
Further research is needed to better understand and assess population disequilibrium for effective genetic epidemiology study design.

Related Experiment Videos