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Active, multisite, laboratory-based surveillance for Cryptosporidium parvum
1Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724, USA.
Abstract:
Cryptosporidium parvum leaped to the attention of the United States following the 1993 outbreak in Milwaukee, Wisconsin, which sickened 400,000 people. Other outbreaks in the United States have been associated with drinking and recreational water, consumption of contaminated foods, contact with animals, and childcare attendance. Despite its public health importance, the number of people who become infected each year is not known. In 1997, active surveillance for C. parvum was added to the Foodborne Diseases Active Surveillance Network (FoodNet), a collaborative effort among the Centers for Disease Control and Prevention, selected state health departments, the U.S. Departments of Agriculture and Food and Drug Administration. During the first 2 years of surveillance, 1,023 laboratory-confirmed cases of cryptosporidiosis were detected in FoodNet (Connecticut, Minnesota, Oregon, and selected counties in California, Georgia, Maryland, and New York). The annual rate per 100,000 persons was 2.3. Sixteen percent of case-patients were hospitalized. A seasonal increase in case detection was noted in late summer among persons less than 15 years of age. These data represent the first active multistate ascertainment of laboratory-confirmed cryptosporidiosis cases and provide useful information on the burden of disease in the United States.
Insights
Cryptosporidium parvum causes widespread illness, with 1,023 cases detected by active surveillance. This research provides crucial data on cryptosporidiosis burden in the United States.
Area of Science:
- Public Health
- Infectious Diseases
- Epidemiology
Background:
- Cryptosporidium parvum outbreaks, like the 1993 Milwaukee incident, highlight its public health significance.
- Transmission routes include contaminated water, food, animal contact, and childcare settings.
- Accurate data on annual infection rates were previously unknown.
Purpose of the Study:
- To establish active surveillance for Cryptosporidium parvum (C. parvum).
- To determine the disease burden of cryptosporidiosis in the United States.
- To provide initial data from the Foodborne Diseases Active Surveillance Network (FoodNet).
Main Methods:
- Implemented active surveillance for C. parvum in 1997.
- Integrated C. parvum surveillance into the FoodNet network.
- Collected laboratory-confirmed cases from selected states.
Main Results:
- Detected 1,023 laboratory-confirmed cases over the first 2 years of surveillance.
- Calculated an annual incidence rate of 2.3 cases per 100,000 persons.
- Observed a 16% hospitalization rate and a seasonal increase in cases among children.
Conclusions:
- This study represents the first active, multistate ascertainment of cryptosporidiosis cases.
- Provides valuable insights into the disease burden of C. parvum in the U.S.
- Highlights the importance of ongoing surveillance for this pathogen.