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Markers of thrombophilia in retinal vein thrombosis
L Hansen1, H L Kristensen, T Bek
1The Department of Ophthalmology, University Hospital Aarhus/Skejby, Aarhus, Denmark. cpom.@dadlnet.dk
Purpose:
To study the prevalence of risk factors for systemic thromboembolism in patients with retinal vein thrombosis (RVT).
Methods:
Fifty-four patients younger than 70 years, diagnosed with a retinal vein thrombosis at the Department of Ophthalmology, Aarhus University Hospital, were examined for the presence of venous thrombosis risk factors.
Results:
23 patients had a central RVT, 26 had a branch RVT, and 4 had a macular RVT. Nineteen (35.2%) of the patients displayed increased levels of plasma homocysteine, one patient (1.9%) the Factor V Leiden mutation, and one patient (1.9%) displayed an antiphospholipid antibody. All other tests for thrombophilia rendered normal. In 15 of the patients with hyperhomocysteinemia, folic acid substitution returned plasma homocysteine to a normal value in 12 cases.
Conclusion:
A surprisingly high prevalence of hyperhomocysteinemia was detected in this cohort of RVT patients, clearly superseding the prevalence of around 17% found in patients suffering venous thromboembolism in other vascular compartments. Our finding points to the likelihood that hyperhomocysteinemia may be a significant risk factor for retinal vein thrombosis.