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[The mechanisms of hyperhomocysteinemia in coronary heart disease]

W Gao1, N Jiang, G Zhu

  • 1First Hospital of Beijing Medical University.

Zhonghua Yi Xue Za Zhi
|October 20, 2000
PubMed

Insights

Hyperhomocysteinemia (HHe) is identified as an independent risk factor for coronary heart disease (CHD). Elevated homocysteine levels are linked to increased risk, independent of traditional lipid profiles.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Genetics

Context:

  • Coronary heart disease (CHD) is a leading cause of mortality worldwide.
  • Traditional risk factors include dyslipidemia, hypertension, and smoking.
  • The role of homocysteine metabolism in CHD pathogenesis requires further elucidation.

Purpose:

  • To investigate hyperhomocysteinemia (HHe) as a novel and independent risk factor for CHD.
  • To examine the association between plasma homocysteine (HCY) levels and CHD.
  • To assess the influence of MTHFR gene mutations and B vitamin status on HCY levels in CHD patients.

Summary:

  • Patients with angiographically confirmed CHD exhibited significantly higher plasma HCY concentrations compared to controls.
  • Elevated HCY levels were observed in patients with myocardial infarction, hypertension, and a family history of CHD.
  • Plasma HCY showed an inverse correlation with folate and vitamin B12 levels and was higher in individuals with MTHFR 677C-->T mutations.

Impact:

  • Establishes hyperhomocysteinemia as an independent risk factor for coronary heart disease.
  • Suggests potential therapeutic targets for CHD prevention by managing HCY levels.
  • Highlights the interplay between genetic factors, B vitamin status, and cardiovascular risk.
Abstract

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