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[Activated C protein resistance manifested by cutaneous necrosis after interferon alpha injection: case report]
F Plurien1, Z Le Lostec, C Pauwels
1Service de médecine interne A, centre hospitalier Poissy-Saint-Germain, Saint-Germain-en-Laye, France.
Introduction:
Cutaneous necrosis occurring in the course of treatment by alpha interferon is an uncommon side-effect. Its physiopathologic mechanism remains obscure. A local thrombotic action of interferon has been suggested to explain its occurrence.
Exegesis:
A 64-year-old male patient with human immunodeficiency virus-related cutaneous Kaposi's sarcoma presented cutaneous necrosis after a 9-month treatment by interferon alpha, while his resistance to activated protein C had already been demonstrated. To our knowledge, this is the first case ever described regarding the association of interferon-induced cutaneous necrosis with activated protein C resistance.
Conclusion:
This suggests that in case of interferon treatment-induced cutaneous necrosis coagulation disorders should be investigated and questions the existence of a particular "pro-coagulant profile" facilitating this side effect.
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