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Convenient procedures for synthesis of ciproxifan, a histamine H3-receptor antagonist
1Institut für Pharmazie, Freie Universität Berlin, Germany.
Archiv Der Pharmazie
|October 20, 2000
Abstract:
Cyclopropyl 4-(3-(1H-imidazol-4-yl)propyloxy)phenyl methanone (ciproxifan) is a novel reference antagonist for the histamine H3 receptor. Despite the former Mitsunobu reaction the actual key reaction for preparation based on SNAr for acylated fluoroaromatics with an additional cyclization in a one-pot procedure needs no chromatographic purification steps and results in good yields.