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Diffusion-tensor MR imaging of the human brain with gradient- and spin-echo readout: technical note.

R Itoh1, E R Melhem, P J Folkers

  • 1Department of Radiology and Radiological Sciences, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.

AJNR. American Journal of Neuroradiology
|October 20, 2000
PubMed
Summary

Gradient- and spin-echo readout offers a promising alternative for diffusion-tensor MR imaging of the brain. This method provides comparable water diffusion measurements to echo-planar imaging with reduced geometrical distortion.

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Area of Science:

  • Neuroimaging
  • Biophysics
  • Medical Physics

Background:

  • Diffusion-tensor MR imaging (DTI) noninvasively measures water diffusion in brain tissue.
  • DTI is crucial for objective assessment of tissue microstructure.
  • Echo-planar imaging (EPI) is a common but distortion-prone DTI technique.

Purpose of the Study:

  • To evaluate gradient- and spin-echo (GRASE) readout for brain DTI.
  • To compare GRASE DTI with single-shot spin-echo echo-planar imaging (SSE-EPI).

Main Methods:

  • Diffusion-tensor imaging was performed on five adult volunteers.
  • Gradient- and spin-echo (GRASE) readout was compared to single-shot spin-echo echo-planar imaging (SSE-EPI).
  • Key metrics included water diffusion measurements and geometrical distortion.

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Main Results:

  • GRASE readout yielded water diffusion measures comparable to SSE-EPI.
  • GRASE readout demonstrated significantly less geometrical distortion than SSE-EPI.
  • The trade-off for reduced distortion was a longer imaging time with GRASE.

Conclusions:

  • Gradient- and spin-echo readout is a viable technique for brain DTI.
  • GRASE offers improved geometrical accuracy over SSE-EPI.
  • GRASE may be advantageous for DTI applications sensitive to geometric distortions.