Related Experiment Videos
Inheritance of human longevity in Iceland
H Gudmundsson1, D F Gudbjartsson, M Frigge
1Decode Genetics Inc, Reykjavik, Iceland.
European Journal of Human Genetics : EJHG
|October 20, 2000
Summary
Genetic factors significantly influence human longevity. First-degree relatives of individuals reaching the 95th percentile of lifespan are nearly twice as likely to achieve this longevity, indicating a strong familial component.
Area of Science:
- Genetics
- Demography
- Gerontology
Background:
- Evidence from other species and limited human studies suggests genetic influence on human longevity.
- Previous studies were limited by small sample sizes, leading to potential sampling error and selection bias.
Purpose of the Study:
- To investigate the genetic component of human longevity using a comprehensive Icelandic genealogy database.
- To examine multigenerational relationships among individuals who reach the 95th percentile of lifespan.
Main Methods:
- Utilized a comprehensive, population-based computerized genealogy database for Iceland.
- Developed a clustering tool to generate large extended pedigrees.
- Applied the Minimum Founder Test (MFT) algorithm to assess familial components of longevity.
Main Results:
- First-degree relatives of individuals in the 95th percentile for longevity were almost twice as likely to reach the 95th percentile compared to controls.
- Significant genetic component identified for longevity.
- Offspring of long-lived parents exhibited significantly lower age-specific death rates, particularly after age 70.
Conclusions:
- Human longevity has a significant genetic component.
- Familial aggregation of extreme longevity is evident.
- Inherited factors contribute to reduced mortality rates in later life.