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Related Experiment Videos

Basic and update knowledge of intervertebral disc herniation: review.

S Yabuki1

  • 1Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima City, Japan.

Fukushima Journal of Medical Science
|October 20, 2000
PubMed
Summary

Lumbar disc herniation causes low back pain and sciatica, often due to inflammation from nucleus pulposus affecting nerve roots. This review highlights the inflammatogenic properties of herniated nucleus pulposus in spinal pain pathogenesis.

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Application of nucleus pulposus to the nerve root simultaneously reduces blood flow in dorsal root ganglion and corresponding hindpaw in the rat.

Spine·2000

Area of Science:

  • Orthopedics
  • Neurology
  • Pain Medicine

Background:

  • Lumbar disc herniation is a primary cause of low back pain and sciatica.
  • The precise mechanisms underlying lumbar disc herniation, low back pain, and sciatica remain incompletely understood.
  • Historically, herniated nucleus pulposus was misidentified as an enchondroma of the intervertebral disc.

Observation:

  • The nucleus pulposus, when herniated, can induce inflammation in the nerve root and dorsal root ganglia.
  • This inflammation is increasingly recognized as a key factor in the development of spinal pain.
  • Review of current literature provides updated insights into lumbar disc herniation.

Findings:

  • Herniated nucleus pulposus possesses significant inflammatogenic properties.

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  • These properties directly impact nerve root function and structural integrity.
  • Alterations in nerve root vascular permeability are observed.

    • Implications:

    • Understanding the inflammatogenic role of nucleus pulposus is crucial for developing targeted therapies for spinal pain.
    • This knowledge advances the understanding of lumbar disc herniation pathogenesis.
    • Potential for novel treatment strategies targeting inflammatory pathways in nerve roots.