Related Experiment Video

Updated: Oct 11, 2026

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging
10:16

Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging

Published on: February 10, 2012

Contrast enhanced electron beam computed tomography to analyse the coronary arteries in patients after acute

S Achenbach1, D Ropers, M Regenfus

  • 1Department of Internal Medicine II, University of Erlangen-Nürnberg, Ostliche Stadtmauerstr 29, D-91054 Erlangen, Germany. stephan.achenbach@rzmail.uni-erlangen.de

Heart (British Cardiac Society)
|October 20, 2000
PubMed

Insights

Contrast enhanced electron beam computed tomography (EBCT) accurately detects coronary artery lesions after myocardial infarction. However, EBCT is currently unreliable for differentiating between occluded and patent infarct-related arteries.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Diagnostic Technology

Background:

  • Acute myocardial infarction (AMI) necessitates accurate assessment of coronary artery status.
  • Electron beam computed tomography (EBCT) is a non-invasive imaging modality for cardiac evaluation.

Purpose of the Study:

  • To assess the diagnostic accuracy of contrast-enhanced EBCT in identifying coronary artery patency, high-grade stenoses, and occlusions post-AMI.
  • To compare EBCT findings with invasive coronary angiography (ICA).

Main Methods:

  • A case study involving 36 patients (mean age 53) 4-70 days post-AMI.
  • EBCT with contrast was performed, acquiring 50 axial images per patient.
  • EBCT results were compared blindly against ICA findings.

Main Results:

  • EBCT was unevaluable in 20% of coronary arteries.
  • High-grade stenoses were detected with 92% sensitivity and 92% specificity.
  • Artery patency post-MI was correctly identified in 94% of cases.

Conclusions:

  • Contrast-enhanced EBCT demonstrates high accuracy in detecting significant coronary artery lesions in patients after AMI.
  • Current EBCT technology shows limitations in reliably distinguishing between occluded and patent infarct-related arteries.
Abstract

More Related Videos

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease12:15

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease

Published on: February 8, 2022

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Related Concept Videos

Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...