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Related Experiment Videos

Endogenous circulating sympatholytic factor in orthostatic intolerance.

R E Shapiro1, B Winters, M Hales

  • 1Department of Neurology, College of Medicine, University of Vermont, Burlington, USA.

Hypertension (Dallas, Tex. : 1979)
|October 21, 2000
PubMed
Summary
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More perfect - in reply.

International journal of obstetric anesthesia·2017

A novel factor in sympathotonic orthostatic hypotension (SOH) plasma selectively blocks alpha(1B)-adrenergic receptors, explaining severe blood pressure issues. This discovery offers new insights into SOH pathogenesis and alpha(1)-adrenergic receptor function.

Area of Science:

  • Cardiovascular Physiology
  • Neuroendocrinology
  • Pharmacology

Background:

  • Sympathotonic orthostatic hypotension (SOH) is an idiopathic condition causing symptoms like rapid heart rate and low blood pressure upon standing.
  • This patient presented with severe, progressive SOH and unresponsiveness to medications that constrict blood vessels.

Observation:

  • Patient plasma inhibited vasoconstriction in blood vessels exposed to adrenergic agonists.
  • This effect was specific to adrenergic stimuli and did not impact responses to other vasoconstrictors.
  • Plasma from SOH patients interfered with the binding of a specific alpha(1)-adrenergic receptor antagonist.

Findings:

  • A circulating factor in the patient's plasma selectively and irreversibly inhibits ligand binding to alpha(1B)-adrenergic receptors.
Keywords:
NASA Discipline CardiopulmonaryNASA Program Biomedical Research and CountermeasuresNon-NASA Center

Related Experiment Videos

  • This inhibition was observed in various tissues, including porcine pulmonary artery, rat liver, and cell lines expressing alpha(1B)-adrenergic receptors.

    • Implications:

    • This finding suggests a novel mechanism contributing to SOH in this patient.
    • The identified factor may represent a new disease entity and a valuable tool for studying alpha(1)-adrenergic receptor subtypes.