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[Viscumin modulates neutrophil respiratory burst, caused by a chemotactic peptide]
A A Alovskaia1, V G Safronova, V V Kornilov
1Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Biofizika
|October 21, 2000
Abstract:
The ability of viscum at different concentrations to modulate the respiratory burst in neutrophils, induced by the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine was studied. This does not exclude the possibility that viscum can interact with the receptor of this peptide. The analysis of the primary structure of viscum revealed elements structurally analogous to the chemotactic peptide. It is assumed that viscum can exhibit the properties an antagonist of the receptor of N-formyl-methionyl-leucyl-phenylalanine, and the mechanism of action of viscum depends on its concentration.