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Lipid metabolism in the elderly.

M J Toth1, A Tchernof

  • 1Department of Medicine, University of Vermont, Burlington 05405, USA. mtoth@zoo.uvm.edu

European Journal of Clinical Nutrition
|October 21, 2000
PubMed
Summary

As people age, their bodies become less efficient at burning fat. This decline in fat oxidation, particularly in muscle tissue, contributes to increased body fat with age.

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Area of Science:

  • Gerontology
  • Metabolism
  • Physiology

Background:

  • Adiposity, or body fat, tends to increase with age.
  • This increase is linked to the balance between fat release from adipose tissue and its oxidation by other tissues.
  • Understanding age-related changes in fat metabolism is crucial for addressing obesity.

Purpose of the Study:

  • To review the effects of aging on free fatty acid release from adipose tissue.
  • To examine how aging impacts the capacity of respiring tissues to oxidize fat.
  • To identify the primary drivers of age-related increases in adiposity.

Main Methods:

  • In vitro studies on lipolysis in adipocytes.
  • In vivo studies assessing fatty acid mobilization and oxidation.
  • Review of existing literature on age-related fat metabolism.

Main Results:

  • In vitro studies show reduced lipolysis with age.
  • In vivo studies indicate excess fatty acid release in older individuals.
  • A significant decline in the capacity of respiring tissues, especially skeletal muscle, to oxidize fat with age.

Conclusions:

  • The age-related decrease in fat oxidation capacity in respiring tissues is a more significant factor in increased adiposity than reduced fatty acid release.
  • Interventions targeting the mass or oxidative capacity of respiring tissues could help mitigate age-related fat accumulation.

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