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Updated: Oct 11, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Paraoxonase polymorphisms, pesticide exposure and Parkinson's disease in a Caucasian population
M C Taylor1, D G Le Couteur, G D Mellick
1Molecular Genetics Group, John Curtin School of Medical Research, Acton, ACT, Australia.
Abstract:
Parkinson's disease (PD) has been associated with exposure to pesticides and oxidative injury. The involvement of paraoxonase in both pesticide metabolism and lipid peroxidation suggests that it may play a role in the pathogenesis of PD. We examined the frequency of polymorphic alleles of the PON1 and PON2 genes in a sample of caucasian subjects with PD. The frequency distribution of these genotypes did not differ significantly between patients and controls, including those who had reported exposure to pesticides.
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