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Juvenile myelomonocytic leukemia relapsing after allogeneic bone marrow transplantation successfully treated with
1Department of Developmental Medicine (Pediatrics), Osaka Utniversihv Graduate School of Medicine, Suita, Japan.
Bone Marrow Transplantation
|October 21, 2000
Abstract:
We report a 5-year-old boy with juvenile myelomonocytic leukemia (JMML) which relapsed after an allogeneic bone marrow transplant who was successfully treated with interferon-alpha (IFN-alpha). One year after starting the therapy, he remains clinically well and in complete remission while continuing treatment with IFN-alpha and bestatin. Although the precise mechanism by which remission was induced is uncertain, a GVL effect combined with a direct antileukemia effect of IFN-alpha may be responsible. Further assessment of the role of IFN-alpha in relapsed JMLL patients is warranted.