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Related Experiment Videos

Maternal age and malformations in singleton births.

L M Hollier1, K J Leveno, M A Kelly

  • 1Department of Obstetrics & Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. lisa.m.hollier@uth.tmc.edu

Obstetrics and Gynecology
|October 24, 2000
PubMed
Summary

Advanced maternal age increases the risk of fetal congenital malformations not linked to chromosomal abnormalities. This study found a progressive rise in nonchromosomal malformations in women aged 25 and older.

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Area of Science:

  • Reproductive Medicine
  • Medical Genetics
  • Obstetrics

Background:

  • Maternal age is a known factor influencing pregnancy outcomes.
  • Previous research has linked advanced maternal age to chromosomal abnormalities.
  • The impact of maternal age on nonchromosomal fetal malformations requires further investigation.

Purpose of the Study:

  • To investigate the association between maternal age and the incidence of nonchromosomal fetal malformations.
  • To quantify the increased risk of specific congenital anomalies with advancing maternal age.

Main Methods:

  • Prospective cataloging of malformations in 102,728 pregnancies (1988-1994).
  • Maternal age categorized into seven epochs.
  • Relative risks and Mantel-Haenszel chi-squared statistic used for comparisons.

Related Experiment Videos

  • Logistic regression adjusted for parity.

    • Main Results:

    • Increased incidence of structurally malformed infants in women aged 25 and older, even after excluding chromosomal abnormalities.
    • A progressive increase in nonchromosomal malformations observed with advancing maternal age.
    • Significantly higher odds ratios for cardiac defects in infants of women aged 40+; increased risks for clubfoot and diaphragmatic hernia also noted.

    Conclusions:

    • Advanced maternal age (beyond 25 years) is significantly associated with an elevated risk of congenital malformations not caused by aneuploidy.
    • Specific malformations, including cardiac defects, clubfoot, and diaphragmatic hernia, show increased risk with higher maternal age.