Related Experiment Video
Updated: Oct 11, 2026

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
Published on: March 1, 2019
The genetic basis for cytopathogenicity of pestiviruses
B M Kümmerer1, N Tautz, P Becher
1Federal Research Center for Virus Diseases of Animals, Paul-Ehrlich-Str. 28, D-72076, Tübingen, Germany.
Abstract:
Two biotypes of pestiviruses, cytopathogenic (cp) and noncp viruses, can be distinguished by their effects on tissue culture cells. Identification of cp bovine viral diarrhea virus (BVDV) has been frequently reported since antigenically closely related noncp and cp BVDV can be isolated from cattle with fatal mucosal disease (MD) and are called a virus pair. In contrast to the BVDV system, only few cp border disease virus (BDV) and cp classical swine fever virus (CSFV) strains have been described. Serological analyses and sequence comparison studies showed that cp pestiviruses arise from noncp viruses by mutation. Elaborate studies during the last 10 years revealed that in most cases RNA recombination is responsible for the generation of the cp viruses. Recent results showed a second way for the development of a cp pestivirus which is based on the introduction of a set of point mutations within the NS2 gene.
More Related Videos
Related Concept Videos
Viral Structure
Determinants of Bacterial Pathogenicity and Virulence
Retroviruses
Subviral Agents
Size and Structure of Viral Genomes
Viruses with RNA Genomes

