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Nucleotide sugar transporters of the Golgi apparatus
P M Berninsone1, C B Hirschberg
1Department of Molecular and Cell Biology, Boston University, School of Dental Medicine, 700 Albany Street, W-200, MA 02118, Boston, USA.
Current Opinion in Structural Biology
|October 24, 2000
Abstract:
Glycosylation, sulfation and phosphorylation of proteins, proteoglycans and lipids occur in the lumen of the Golgi apparatus. The nucleotide substrates of these reactions must be first transported from the cytosol into the Golgi lumen by specific transporters. The topology and structure of these hydrophobic, multi-transmembrane-spanning proteins are beginning to be understood.