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Lymphomatoid granulomatosis: radiologic features and pathologic correlations.

J S Lee1, R Tuder, D A Lynch

  • 1Department of Radiology, Health Sciences Center, University of Colorado School of Medicine, 4200 E. 9th Ave., Box A030, Denver, CO 80262, USA.

AJR. American Journal of Roentgenology
|October 24, 2000
PubMed
Summary

This study defines the characteristic CT imaging features of lymphomatoid granulomatosis, a rare condition involving atypical lymphoid cells. Findings correlate radiologic signs with histopathology for improved diagnosis.

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Area of Science:

  • Radiology
  • Pathology
  • Oncology

Background:

  • Lymphomatoid granulomatosis is a rare lymphoproliferative disorder.
  • Accurate diagnosis relies on integrating imaging and histopathology.

Purpose of the Study:

  • To define the distinct radiologic features of lymphomatoid granulomatosis.
  • To correlate computed tomography (CT) findings with histopathologic characteristics.

Main Methods:

  • Review of radiologic imaging (CT) in patients diagnosed with lymphomatoid granulomatosis.
  • Correlation of imaging findings with histopathologic confirmation.

Main Results:

  • Characteristic CT findings include peribronchovascular nodules, irregular opacities, and cysts.

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  • Large masses and vascular occlusion can also be present.
  • Histopathology reveals intravascular and perivascular infiltration by atypical lymphoid cells.
  • Conclusions:

    • Lymphomatoid granulomatosis exhibits specific CT imaging patterns.
    • Radiologic features are consistent with intravascular and perivascular lymphoid infiltration.