Related Experiment Videos
beta(2)-adrenergic agonists and pelvic floor exercises for female stress incontinence
O Ishiko1, T Ushiroyama, F Saji
1Department of Obstetrics and Gynecology, Osaka City University Medical School, Osaka, Japan. ishikoo@msic.med.osaka-cu.ac.jp
Objective:
We compared beta(2)-adrenergic agonist therapy with clenbuterol (DT) and physiological therapy (PT) in a randomized study to establish the first line therapy for stress incontinence (SI).
Method:
The clinical efficacy of DT (group A), PT (group B), and a combination of DT and PT (group C) was investigated in 61 patients with SI by means of a 12-week randomized controlled study. The frequency and volume of SI and the patients' own impressions were used as the basis for the assessment of efficacy.
Results:
The SI improvement rates in groups A, B, and C were 76.9, 52.6, and 89. 5%, respectively (P=0.0361). A significant therapeutic effect on the frequency of SI was observed in group B and group C at 2 weeks after the start of treatment (both P<0.05), and in all groups at 6 weeks (all P<0.01). The efficacy rates based on the patients' own impressions in groups A, B, and C were 84.6, 31.6, and 68.4%, respectively (P=0.0064).
Conclusion:
The beta(2)-adrenergic agonist appeared to be clinically useful as a drug of choice for SI.