Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasminogen did not affect lung function in surfactant-treated preterm lambs.

V Bhat1, A H Jobe, S Wert

  • 1Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.

Biology of the Neonate
|October 25, 2000
PubMed
Summary

Plasminogen administration did not improve lung function or prevent hyaline membrane formation in preterm lambs with respiratory distress syndrome. This study suggests plasminogen supplementation is not effective in treating this condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chorioamnionitis induces enteric nervous system injury: effects of timing and inflammation in the ovine fetus.

Molecular medicine (Cambridge, Mass.)·2020
Same author

Clinical interventions to reduce stillbirths in sub-Saharan Africa: a mathematical model to estimate the potential reduction of stillbirths associated with specific obstetric conditions.

BJOG : an international journal of obstetrics and gynaecology·2016
Same author

The clinical use of corticosteroids in pregnancy.

Human reproduction update·2015
Same author

Antenatal exposure to chorioamnionitis affects lipid metabolism in 7-week-old sheep.

Journal of developmental origins of health and disease·2014
Same author

Antenatal ureaplasma infection impairs development of the fetal ovine gut in an IL-1-dependent manner.

Mucosal immunology·2012
Same author

What is BPD in 2012 and what will BPD become?

Early human development·2012

Area of Science:

  • Neonatal Physiology
  • Pulmonary Medicine
  • Biochemistry

Background:

  • Respiratory distress syndrome (RDS) in preterm infants involves fibrin deposition and reduced fibrinolysis, potentially due to plasminogen deficiency.
  • Fibrin accumulation impairs surfactant function and exacerbates lung inflammation.
  • Targeting fibrinolysis is a potential therapeutic strategy for RDS.

Purpose of the Study:

  • To investigate if plasminogen administration could prevent hyaline membrane formation and improve lung function in surfactant-treated preterm lambs.
  • To assess the impact of plasminogen on lung pathology and physiological parameters in a model of RDS.

Main Methods:

  • Preterm lambs (127-129 days gestation) were randomly assigned to receive either lysine-plasminogen or saline.

Related Experiment Videos

  • Lambs were ventilated for 5 hours post-treatment.
  • Lung function, lung injury markers, and hyaline membrane formation were evaluated.

    • Main Results:

    • No significant differences were observed in lung function indices (ventilation efficiency, oxygenation, compliance, pressure-volume curves) between groups.
    • Measures of lung injury (protein content, albumin recovery) and surfactant pool size were similar.
    • The extent of bronchiolar erosion and hyaline membrane formation did not differ between plasminogen-treated and control lambs.

    Conclusions:

    • Plasminogen administration did not ameliorate lung pathology or improve lung function in surfactant-treated preterm lambs.
    • These findings indicate that plasminogen supplementation is not effective in preventing hyaline membrane formation in this model of RDS.