[Anticoagulation therapy and bone metabolism]

The effect of anticoagulation treatment with coumarin and heparin on bone metabolism is in recent years frequently discussed in professional journals. Its ever expanding use in the treatment of patients deserves therefore attention in particular in patients having prolonged anticoagulation treatment. In the submitted paper the authors investigated the effect of Warfarin on some indicators of bone metabolism in a group of 17 patients. In the investigated parameters such as estimation of parathormone, serum calcium, phosphatemia, isoenzyme of alkaline phosphatase they did not reveal any statistically significant changes during coumarin treatment.