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Related Experiment Videos

Brain stem tuberculosis in children.

R Kumar1, R Jain, A Kaur

  • 1Department of Neuro-surgery, Sanjay Gandhi Post-graduate Institute of Medical Sciences, Lucknow, India. rajkumar@sgpgi.ac.In

British Journal of Neurosurgery
|October 25, 2000
PubMed
Summary
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Brain stem tuberculomas, a rare form of neurotuberculosis, can affect cranial nerves. Prompt anti-tubercular chemotherapy leads to full recovery in children, with surgery not typically required.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pediatrics

Background:

  • Neurotuberculosis commonly presents as tubercular meningitis or intracranial tuberculomas.
  • Brain stem tuberculomas are rare, comprising 2.5-8% of intracranial tuberculomas.

Purpose of the Study:

  • To describe the clinical presentation, management, and outcomes of pediatric brain stem tuberculosis.
  • To highlight the cranial nerve involvement and response to chemotherapy in these rare cases.

Main Methods:

  • Retrospective case series of six pediatric patients with brain stem tuberculosis.
  • Clinical data including imaging, neurological examination, and treatment response were analyzed.

Main Results:

  • Five patients had well-formed brain stem tuberculomas; one had an ill-defined lesion with concurrent tubercular meningitis.

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  • All six patients exhibited cranial nerve involvement (3rd, 6th, and/or 7th nerves).
  • All patients responded well to anti-tubercular chemotherapy, with full recovery and no residual deficits.

    • Conclusions:

    • Brain stem tuberculomas in children, though rare, are treatable with anti-tubercular chemotherapy.
    • Cranial nerve palsies are common presenting features.
    • Surgical intervention is generally not indicated for brain stem tuberculomas.