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Synthesis of NG-061 and its analogs, and their biological evaluation as an enhancer of nerve growth factor
T Eguchi1, S Kanai, K Kakinuma
1Department of Chemistry and Materials Science, Tokyo Institute of Technology, Japan.
Chemical & Pharmaceutical Bulletin
|October 25, 2000
Abstract:
A novel potentiator of nerve growth factor (NGF), NG-061, which had been isolated from the fermentation broth of Penicillium minioluteum F-4627, was synthesized from methoxybenzoquinone and phenylacetylhydrazine in a single step. A series of acyl hydrazone derivatives were also synthesized and their potentiator activity of neurotrophic effect of NGF on neurite outgrowth was evaluated by assay with a rat pheochromocytoma cell line PC12.