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Related Experiment Videos

Genome plasticity in Enterobacteriaceae.

W Brunder1, H Karch

  • 1Institut für Hygiene und Mikrobiologie der Universität Würzburg, Germany. wbrunder@hygiene.uni-wuerzburg.de

International Journal of Medical Microbiology : IJMM
|October 25, 2000
PubMed
Summary
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Bacterial genomes are not static but are fluid structures. Gene rearrangement and horizontal gene transfer drive this plasticity, influencing bacterial traits and pathogenicity.

Area of Science:

  • Microbiology
  • Genomics
  • Molecular Biology

Background:

  • Bacterial genomes are increasingly viewed as dynamic and plastic, not static entities.
  • Mechanisms like gene rearrangement and horizontal gene transfer contribute to genome variability.
  • Genomic variations impact bacterial phenotypes, potentially altering pathogenicity.

Purpose of the Study:

  • To review mechanisms of genome rearrangement and horizontal gene transfer in Enterobacteriaceae.
  • To highlight the variability of mobile genetic elements themselves.

Main Methods:

  • Comparative genomic analysis.
  • Literature review of gene transfer systems (plasmids, bacteriophages, transposons, gene cassettes).

Main Results:

Related Experiment Videos

  • Bacterial genomes exhibit significant plasticity due to gene rearrangement and horizontal gene transfer.
  • These processes often act in concert, creating complex genetic structures.
  • Mobile genetic elements are also subject to variation.

Conclusions:

  • Genomic fluidity is a key characteristic of bacteria, influencing their evolution and adaptation.
  • Understanding these mechanisms is crucial for comprehending bacterial pathogenicity and evolution.