Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Error propagation in the hypercycle.

P R Campos1, J F Fontanari, P F Stadler

  • 1Instituto de Física de São Carlos, Universidade de São Paulo, Brazil.

Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics
|October 25, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa.

BMC evolutionary biology·2018
Same author

Hidden treasures in unspliced EST data.

Theory in biosciences = Theorie in den Biowissenschaften·2012
Same author

Metformin inhibits inflammatory angiogenesis in a murine sponge model.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2010
Same author

Identification and classification of small RNAs in transcriptome sequence data.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing·2009
Same author

Sequence assembly.

Computational biology and chemistry·2009
Same author

RNA structures with pseudo-knots: graph-theoretical, combinatorial, and statistical properties.

Bulletin of mathematical biology·2007
Same journal

Efficient Monte Carlo simulations using a shuffled nested Weyl sequence random number generator.

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2002
Same journal

Spatiotemporal dynamics of electromagnetic pulses in saturating nonlinear optical media with normal group velocity dispersion.

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2002
Same journal

Soliton-breather reaction pathways.

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2002
Same journal

Calculation of electromagnetic properties of regular and random arrays of metallic and dielectric cylinders.

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2002
Same journal

Electromagnetic convective cells in a nonuniform dusty plasma.

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2002
Same journal

Stability of neural networks and solitons of field theory.

Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics·2002
See all related articles

A master template enhances stability in self-replicating networks. Hypercycle stability requires higher catalytic coupling strength (K) than chain stability, with the error threshold decreasing as K and network size (n) increase.

Area of Science:

  • Theoretical chemistry
  • Systems biology
  • Biophysics

Background:

  • Self-replicating molecules are fundamental to life's origins.
  • Hypercycles offer a model for cooperative replication but face stability challenges from errors.
  • Understanding the conditions for stable molecular cooperation is crucial for origin-of-life research.

Purpose of the Study:

  • To analytically investigate the steady-state stability of an asymmetric hypercycle network with error-prone templates.
  • To determine the conditions under which a master template ensures network stability against error accumulation.
  • To analyze the relationship between catalytic coupling strength, network size, and the error threshold for hypercycle maintenance.

Main Methods:

  • Analytical study of the steady-state regime.

Related Experiment Videos

  • Mathematical modeling of an n-template asymmetric hypercycle network.
  • Analysis of template coexistence and stability against an error tail.

    • Main Results:

    • A master template with higher intrinsic replication rate stabilizes chains of m < n-1 templates.
    • Chain stability against the error tail is achieved at catalytic coupling strengths (K) on the order of the master template's productivity (a).
    • The hypercycle itself becomes more stable than chains only when K is on the order of a^2.
    • The minimal replication accuracy (error threshold) vanishes as sqrt(n/K) for large K and n <= 4.

    Conclusions:

    • The presence of a superior master template is key to maintaining order in complex replicating systems.
    • Specific catalytic coupling strengths are required to favor hypercyclic organization over simpler chain structures.
    • The error threshold for hypercycle formation is sensitive to network size and coupling strength, suggesting adaptability in early replicators.