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Related Experiment Videos

[Carcinoma in situ in the urinary bladder].

D Katusin, Z Poka, M Mlinac-Lucijanić

    Lijecnicki Vjesnik
    |October 26, 2000
    PubMed
    Summary

    Carcinoma in situ of the urinary bladder, a rare cancer, was diagnosed in seven patients via urine sediment and biopsies. Local immunotherapy or chemotherapy achieved complete response in all patients, with a low recurrence rate.

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    Area of Science:

    • Urology
    • Oncology
    • Pathology

    Context:

    • Carcinoma in situ (CIS) of the urinary bladder is a rare intraepithelial form of transitional cell carcinoma.
    • First described in 1952, CIS presents diagnostic challenges due to potential misinterpretation of irritative urinary symptoms.
    • CIS can occur independently or in association with papillary bladder tumors.

    Purpose:

    • To present seven cases of urinary bladder carcinoma in situ.
    • To highlight diagnostic methods including urine cytology and histopathology.
    • To evaluate treatment outcomes and recurrence rates following local immunotherapy or chemotherapy.

    Summary:

    • Seven patients with urinary bladder CIS were identified through malignant cells in urine sediment and confirmed by random bladder biopsies.
    • Five cases were associated with papillary tumors, while two were primary CIS.
    • All patients experienced a complete response to local immunotherapy or chemotherapy, with a low recurrence rate observed during follow-up (23-61 months).

    Impact:

    • Demonstrates the effectiveness of local immunotherapy and chemotherapy for treating urinary bladder CIS.
    • Emphasizes the importance of considering CIS in patients with irritative urinary symptoms.
    • Provides valuable long-term follow-up data on treatment outcomes and recurrence for this rare condition.

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