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Histopathological and biochemical changes in the sutural region in craniosynostosis
A Pathak1, B K Sandhu, B D Radotra
1Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India. medinst@pgi.chd.nic.in
Object:
Histopathological observations and biochemical analysis of sutural bones in nine patients with craniosynostosis were compared with control subjects of the same age range.
Methods:
Microscopic examination in craniosynostosis showed formation of an active osseous front, with higher osteoblastic activity than in controls. Biochemical analysis revealed higher calcium, phosphorus, alkaline phosphatase, phospholipids and chondroitin sulphate-A contents in sutural bones of the same patients.
Conclusions:
The present study systematically establishes a premature increase in osteogenesis in the sutures of craniosynostosis patients.