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From bench to clinic with apoptosis-based therapeutic agents
1Merck Frosst Centre for Therapeutic Research, Merck Research Laboratories, Pointe Claire-Dorval, Quebec, Canada. donald_nicholson@merck.com
Nature
|October 26, 2000
Summary
Apoptosis, programmed cell death, is fundamental to human disease. Modulating apoptosis offers exciting therapeutic potential, with treatments expected in the clinic soon.
Area of Science:
- Biomedical Science
- Cell Biology
- Pathogenesis Research
Background:
- Apoptosis, or programmed cell death, is a critical factor in the pathogenesis of numerous human diseases.
- Understanding apoptosis is key to developing novel therapeutic strategies.
- Despite challenges, the modulation of cell death pathways presents significant therapeutic opportunities.
Purpose of the Study:
- To review the role of apoptosis in human disease pathogenesis.
- To explore the therapeutic potential of modulating apoptosis.
- To assess the timeline for clinical application of apoptosis-modulating therapies.
Main Methods:
- Retrospective analysis of disease pathogenesis.
- Review of current apoptosis research.
- Evaluation of therapeutic development challenges and prospects.
Main Results:
- Apoptotic processes are consistently implicated in human disease progression.
- Significant therapeutic opportunities arise from targeting apoptosis.
- While challenges exist, clinical applications are anticipated within years.
Conclusions:
- Apoptosis plays a central role in human disease.
- Targeting apoptosis offers promising therapeutic avenues.
- Clinical translation of apoptosis-modulating therapies is expected in the near future.
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