Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progression from allergic sensitization to asthma.

J O Warner1, P Pohunek, C Marguet

  • 1Child Health, University of Southampton/Southampton General Hospital, UK. jow@soton.ac.uk

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|October 26, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Management of asthma attack in children aged 6 to 12 years].

Revue des maladies respiratoires·2024
Same author

Treatment of the congenital thoracic deformity pectus excavatum.

Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti·2024
Same author

[ECOVIR: Study of a primary care cohort in of patients with Acute Respiratory Infections in Normandy, an example of pluri-professional hospital-primary care coordination].

Revue des maladies respiratoires·2022
Same author

[Update guidelines for management of asthmatic patients (from 12 years and older). Short version].

Revue des maladies respiratoires·2022
Same author

[Update of the 2021 Recommendations for the management of and follow-up of adolescent asthmatic patients (over 12 years) under the guidance of the French Society of Pulmonology and the Paediatric Society of Pulmonology and Allergology. Long version].

Revue des maladies respiratoires·2022
Same author

CT findings predicting lung resection in children with complicated community-acquired pneumonia.

Pediatric surgery international·2022
Same journal

Comment on Elhani et al.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

Bridging Rare to Common Diseases: Precision Medicine and the Transforming Landscape of Pediatric Allergy and Immunology.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

Involution of IgE sensitization to house dust mite allergen molecules by age.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

Early initiation of inhaled corticosteroid-long-acting β<sub>2</sub>-agonist therapy and reduction of severe asthma exacerbations in high-risk preschool children: A longitudinal real-world cohort study.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

The role of dog keeping in the home microbiota and its impact on children's health.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

PGM3-SCID: Differential impact of glycosylation on lymphocyte lineage development and function.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
See all related articles

Early life allergen exposure can lead to asthma development. Identifying at-risk infants before irreversible airway changes is crucial for effective asthma prevention strategies.

Area of Science:

  • Immunology
  • Allergy
  • Respiratory Medicine

Background:

  • Asthma is a common atopic disease linked to allergies.
  • Early postnatal exposure to aeroallergens increases sensitization and chronic asthma risk.

Purpose of the Study:

  • To elucidate the immunopathological mechanisms of asthma development.
  • To highlight the critical window for intervention in preventing irreversible airway changes.

Main Methods:

  • The study proposes a model of asthma development based on existing literature.
  • It integrates concepts of in utero sensitization, postnatal allergen exposure, viral infections, and inflammatory cell recruitment.

Main Results:

  • High postnatal allergen exposure, following in utero sensitization, directs airway inflammation.

Related Experiment Videos

  • Viral infections can act as adjuvants, promoting eosinophil and neutrophil recruitment.
  • This leads to epithelial damage, airway remodeling, and eventual asthma symptoms.

    • Conclusions:

    • Asthma immunopathology is established before symptom onset.
    • Early identification of at-risk individuals is essential for preventing irreversible airway remodeling.
    • Future strategies should focus on pre-symptomatic intervention.