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Related Experiment Videos

Can immunization affect the development of allergy?

G Pershagen1

  • 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|October 26, 2000
PubMed
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Infections may influence asthma and allergy prevalence. While some vaccinations show limited impact, certain infections might protect against allergies, potentially increasing risk with vaccination.

Area of Science:

  • Immunology
  • Epidemiology
  • Allergy Research

Background:

  • Rising prevalence of asthma and allergic diseases in developed nations coincides with changing infection patterns.
  • An inverse relationship between sibling numbers and atopy suggests a potential protective role for infections, though evidence is inconclusive.
  • Studies on tuberculin response, BCG vaccination, and pertussis immunization show mixed or limited associations with atopic disorders.

Purpose of the Study:

  • To review the evidence linking infections and vaccinations to the development of atopic diseases.
  • To explore the potential protective effects of infections against allergies.
  • To assess the role of specific infections and immunizations in modulating atopy.

Main Methods:

  • Review of epidemiological studies and clinical trials investigating the relationship between infections, vaccinations, and atopy.

Related Experiment Videos

  • Analysis of data on tuberculin responses, BCG vaccination, pertussis immunization, and viral infections (RSV, hepatitis A, measles).
  • Evaluation of IgE antibody production and atopic manifestations following immunization and infection.

    • Main Results:

    • Limited evidence supports a direct role of vaccinations in causing atopic manifestations, with some vaccines showing no significant enhancement of atopy.
    • Viral infections demonstrate varied effects, with RSV potentially promoting atopy, while hepatitis A and measles may inhibit it.
    • Some infections appear to confer protection against allergies, suggesting vaccination might alter this protective effect.

    Conclusions:

    • The direct impact of vaccinations on atopic disease development is not strongly supported, and some vaccines may have minimal effects.
    • Certain infections may play a protective role in allergy development.
    • Vaccination strategies could potentially influence the risk of allergic diseases by altering exposure to protective infections.